Publications

Contributing to mosquito genomics research

2025 3 publications
ScienceIn press

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk

Crawford JE, Balcazar D, Redmond S, Rose NH, Youd HA, Lucas ER, Sudirman Made Ali R, Alnazawi A, Badolo A, Chen C-H, Cosme LV, et al.

An 8-year international collaboration involving 40+ researchers from 19 institutions analyzing 1,206 Aedes aegypti genomes. Led by Dr. Jacob Crawford (Verily/Alphabet), this community effort reveals how the Atlantic Slave Trade shaped modern mosquito populations and disease transmission patterns.

Ecol Evol

Population Structure of the Invasive Asian Tiger Mosquito, Aedes albopictus, in Europe

Corley MK, Marzec S, Mushegian A, Shen J, Zhao H, Cosme LV, Armbruster P, Powell JR, Caccone A

Comprehensive genomic analysis of Aedes albopictus invasion across Europe revealing multiple independent introductions, rapid cold adaptation through selection on photoperiod and cold tolerance genes, and the Alps as a major barrier to gene flow.

Sci Rep

High voltage-gated sodium channel gene diversity in Aedes albopictus across Brazil

Nascimento RM, Cosme LV, de Souza Alves CC, Fradico J, Rivas Fortes C, de Azevedo Felix MT, da Silva Neves NA, Martins AJ

First nationwide assessment of NaV gene diversity in Brazilian Aedes albopictus populations using pooled next-generation sequencing reveals high genetic variation but absence of kdr mutations despite documented pyrethroid use.

2024 1 publication
Par & Vectors

A genotyping array for the globally invasive vector mosquito, Aedes albopictus

Cosme LV, Corley MK, Johnson T, Severson DW, Yan G, Wang X, et al.

Development and validation of the first comprehensive genotyping array for Aedes albopictus containing 175,396 SNPs, enabling large-scale population genomics studies for tracking invasions, gene flow, and insecticide resistance evolution.

In Revision 1 publication
In Revision

Genome-wide association analysis identifies naturally segregating genetic variation associated with the rapid evolution of diapause in Aedes albopictus

Cosme LV, Corley MK, Shen J, Zhao H, Mushegian A, Marzec S, Armbruster P, Caccone A

First genome-wide association study revealing the genetic architecture of rapid diapause evolution in Aedes albopictus during North American invasion. Identified 5 SNPs on chromosome 1 strongly associated with photoperiodic diapause.

2022 2 publications
Infect Genet Evol

Origins of high latitude introductions of Aedes aegypti to Nebraska and Utah during 2019

Gloria-Soria A, Shragai T, Ciota AT, Duval TB, Alto BW, Martins AJ, Westby KM, Medley KA, Cosme LV, et al.

A population genetics study investigating the source of Aedes aegypti introductions to two unexpected northern US locations (York, Nebraska and Moab, Utah) in 2019.

Front Genet

Genome-wide association study reveals new loci associated with pyrethroid resistance in Aedes aegypti

Cosme LV, Lima JBP, Powell JR, Martins AJ

First genome-wide association study identifying novel genetic loci associated with deltamethrin resistance in Aedes aegypti, revealing the polygenic nature of pyrethroid resistance beyond known resistance genes.

2020 4 publications
PLOS NTD

Evolution of kdr haplotypes in worldwide populations of Aedes aegypti: Independent origins of the F1534C kdr mutation

Cosme LV, Gloria-Soria A, Caccone A, Powell JR, Martins AJ

Demonstrated that the F1534C knockdown resistance (kdr) mutation evolved independently at least twice in global Aedes aegypti populations, revealing convergent evolution under insecticide pressure.

Par & Vectors

Species and sex-specific chemosensory gene expression in Anopheles coluzzii and An. quadriannulatus antennae

Athrey G, Cosme LV, Popkin-Hall Z, Takken W, Slotman M

A comparative transcriptomics study examining chemosensory gene expression differences between sexes and species in the malaria vectors Anopheles coluzzii (anthropophilic) and An. quadriannulatus (zoophilic).

Genome Biol

Improved reference genome of the arboviral vector Aedes albopictus

Palatini U, Masri RA, Cosme LV, et al.

High-quality genome assembly and annotation for the Asian tiger mosquito enabling comparative genomics studies.

Par & Vectors

Genetic structure of the mosquito Aedes aegypti in local forest and domestic habitats in Gabon and Kenya

Xia S, Cosme LV, Lutomiah J, Sang R, Ngangue MF, Rahola N, Ayala D, Powell JR

A population genetics study examining the genetic structure of Aedes aegypti populations living in forest versus domestic habitats in two African locations - La Lopé, Gabon and Rabai, Kenya.

2017 1 publication
Evol Appl

Effective population sizes of a major vector of human diseases, Aedes aegypti

Saarman NP, Gloria-Soria A, Anderson EC, Evans BR, Pless E, Cosme LV, et al.

A comprehensive study estimating the effective population size (Ne) of Aedes aegypti using temporal sampling methods across 17 globally distributed localities.

2011 1 publication
Rev Bras Entomol

Toxicological and ultrastructural analysis of the impact of pesticides used in temperate fruit crops on two populations of Chrysoperla externa

Moura AP, Carvalho GA, Cosme LV, Alves E, Botton M, Silva PS

A comprehensive toxicological study examining the effects of six pesticides used in temperate fruit production on the green lacewing Chrysoperla externa, a key biological control agent.

2009 2 publications
J Econ Ent

Stimulatory Sublethal Response of a Generalist Predator to Permethrin: Hormesis, Hormoligosis, or Homeostatic Regulation?

Guedes NMP, Guedes RNC, Ferreira GH, Cosme LV, Silva LB

A pioneering study demonstrating hormetic responses in the generalist predator Podisus distinctus exposed to sublethal doses of the pyrethroid permethrin.

Arq Inst Biol

Toxicidade de inseticidas botânicos e sintéticos sobre ovos e larvas de Chrysoperla externa (Neuroptera: Chrysopidae)

Cosme LV, Carvalho GA, Moura AP, Parreira DS

Evaluated neem oil (azadirachtin) effects on Chrysoperla externa, a key predator of agricultural pests, to ensure compatibility with biological control programs.

2007 1 publication
Arq Inst Biol

Seletividade de óleo de nim (Azadirachta indica A. Juss) a ovos e larvas de Cycloneda sanguinea (L.) (Coleoptera: Coccinellidae)

Cosme LV, Carvalho GA, Moura AP

Tested neem oil and synthetic insecticides on eggs and larvae of Cycloneda sanguinea, a major aphid predator in Brazilian agroecosystems.

2006 1 publication
Neotrop Ent

Flutuação populacional de adultos de Chrysoperla externa (Hagen, 1861) (Neuroptera: Chrysopidae) em cafeeiros conduzidos em sistemas orgânico e convencional

Silva RA, Carvalho GA, Carvalho CF, Cosme LV

A three-year field study comparing population dynamics of the green lacewing Chrysoperla externa in organic versus conventional coffee production systems in Minas Gerais, Brazil.

2005 2 publications
Neotrop Ent

Toxicidade de Produtos Fitossanitários Utilizados na Cultura do Cafeeiro a Larvas de Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) e Efeitos Sobre as Fases Subsequentes do Desenvolvimento do Predador

Silva RA, Carvalho GA, Carvalho CF, Cosme LV

A comprehensive toxicological study evaluating the selectivity of six pesticides commonly used in coffee production to the green lacewing Chrysoperla externa.

Neotrop Ent

Seletividade de inseticidas registrados para a cultura do crisântemo a ovos e ninfas de Orius insidiosus (Say) (Hemiptera: Anthocoridae)

Carvalho LM, Carvalho GA, Carvalho CF, Cosme LV

A study evaluating the selectivity of five insecticides registered for chrysanthemum crops to the predatory bug Orius insidiosus.

2004 2 publications
Ciênc Agrotec

Avaliação de seletividade de produtos fitossanitários utilizados na cultura do crisântemo a adultos de Orius insidiosus (Say) (Hemiptera: Anthocoridae)

Morais SAB, Carvalho GA, Cosme LV, Carvalho CF, Santa-Cecília LVC

A comprehensive study evaluating the selectivity of five insecticides used in chrysanthemum production to the predatory bug Orius insidiosus.

Neotrop Ent

Seletividade de seis inseticidas utilizados em citros a pupas e adultos de Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae)

Godoy MS, Carvalho GA, Cosme LV, Goussain MM, Carvalho CF

A comprehensive study evaluating the selectivity of six insecticides commonly used in citrus crops to pupae and adults of the green lacewing Chrysoperla externa.