S4

Linkage Network Analysis

LDna (v2.15) identifies Single-Outlier Clusters of SNPs in high linkage disequilibrium on chromosomes 1, 2, and 3.

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File S4 is organized as five notebooks. The first prepares the per-chromosome LD matrices, the next three run LDna on each chromosome, and the last combines the Single-Outlier Cluster (SOC) results genome-wide.

File S4 — five parts

S4a LDna data preparation

Per-chromosome LD matrix construction from the filtered SNP chip genotypes, ready for LDna.

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S4b LDna — chromosome 1

Single-Outlier Cluster detection on chromosome 1.

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S4c LDna — chromosome 2

Single-Outlier Cluster detection on chromosome 2.

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S4d LDna — chromosome 3

Single-Outlier Cluster detection on chromosome 3.

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S4e Combined LDna results

Genome-wide summary of Single-Outlier Clusters across chromosomes 1–3.

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Method. All five notebooks run in the project container ghcr.io/cosmelab/aealbo_autogeny:latest and use the LDna package (v2.15, Kemppainen et al. 2015). The CLI pipeline equivalent is scripts/05_ldna/run_ldna.sh in the repository.