Vector Biology & Mosquito Genomics
University of California, Riverside
The Cosme Lab at UC Riverside is validating cost-effective linked-read sequencing method to generate phased haplotypes for tracking insecticide resistance evolution in California mosquito populations (PacVec Training Grant). Our lab is approved by UCR EHS for vector competence bioassays, enabling us to investigate cellular mechanisms of dengue resistance using single-cell RNA-seq approaches (Regents Fellowship). Beyond mosquitoes, we're developing a robotic vertical farming prototype for sustainable mealworm protein production (Delfino Innovation Grant).
Through these integrated approaches, we aim to understand how disease vectors rapidly evolve and adapt, providing genomic tools that directly inform vector control strategies while pioneering sustainable protein alternatives.
Tracking insecticide resistance evolution through haplotype-resolved sequencing
Understanding genetic mechanisms of pathogen transmission
Mapping rapid evolution of photoperiodic diapause
Validating a cost-effective method for phased haplotypes
Partnering with vector control districts for real-world impact
Containerized workflows for complete reproducibility
Tracking pyrethroid resistance haplotypes in California Aedes aegypti populations while training two undergraduate students
Single-cell RNA-seq to understand dengue resistance mechanisms in mosquitoes
Robotic vertical farming for sustainable mealworm protein production
All our tools, data, and analyses are publicly available through containerized workflows, ensuring complete reproducibility of our research.